Jerry, Bill, Mary, and Denise are two couples out on the road in hopes of writing a book on offbeat roadside attractions. When the four meet Captain Spaulding, they learn of the legend of Dr. Satan. When the four take off in search of finding the tree that Dr. Satan was hung from, they pick up hitchhiker Baby. When their car breaks down, Baby invites them into her house. This is where the two couples meet the Firefly family, a murderous clan of bizarre people. As the family attacks the unsuspecting couples, Jerry and his friends try to survive the house of 1000 corpses and its dark secrets.